Because orthodontic tooth movement is dependent upon osteoclast-mediated resorption of alveolar bone, biologic mediators that regulate osteoclasts can be utilized to control tooth movement. Our goal is to develop a novel method to locally enhance orthodontic anchorage, without significant systemic effects. We encapsulated recombinant osteoprotegerin (OPG) in polymer microspheres and tested the effectiveness of microsphere encapsulated vs. non-encapsulated OPG for enhancing orthodontic anchorage in a previously established rodent model of tooth movement.
Show that pharmacological approach to control of orthodontic tooth movement has the potential to be an effective adjunct to conventional orthodontic methods of anchorage preservation.
Demonstrate the difference in local as well as systemic effects between the single and multiple dose of drug injections.
Comprehend the limitation of current findings and to explore possible future directions.